ParkinsonCanadaV1, Main, Exploration, bibRecord, 000477

Vascular parkinsonism: Deconstructing a syndrome

Identifieur interne : 000477 ( Main/Exploration ); précédent : 000476; suivant : 000478

Vascular parkinsonism: Deconstructing a syndrome

Auteurs : Joaquin A. Vizcarra [Pérou] ; Anthony E. Lang [Canada] ; Kapil D. Sethi [États-Unis] ; Alberto J. Espay [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2015.

RBID : PMC:4478160

English descriptors

KwdEn :
- Cerebrovascular Disorders (classification), Cerebrovascular Disorders (pathology), Cerebrovascular Disorders (physiopathology), Humans, Parkinsonian Disorders (classification), Parkinsonian Disorders (pathology), Parkinsonian Disorders (physiopathology), Syndrome.
MESH :
- classification : Cerebrovascular Disorders, Parkinsonian Disorders.
- pathology : Cerebrovascular Disorders, Parkinsonian Disorders.
- physiopathology : Cerebrovascular Disorders, Parkinsonian Disorders.
- Humans, Syndrome.

Abstract

Progressive ambulatory impairment and abnormal white matter signal on neuroimaging come together under the diagnostic umbrella of vascular parkinsonism. A critical appraisal of the literature, however, suggests that (1) no abnormal structural imaging pattern is specific to vascular parkinsonism; (2) there is poor correlation between brain magnetic resonance imaging hyperintensities and microangiopathic brain disease and parkinsonism from available clinicopathologic data; (3) pure parkinsonism from vascular injury (“definite” vascular parkinsonism) consistently results from ischemic or hemorrhagic strokes involving the substantia nigra and/or nigrostriatal pathway but sparing the striatum itself, the cortex, and the intervening white matter; and (4) many cases reported as vascular parkinsonism may represent pseudovascular parkinsonism (e.g., Parkinson disease or another neurodegenerative parkinsonism such as progressive supranuclear palsy with non-specific neuroimaging signal abnormalities), vascular pseudoparkinsonism (e.g., akinetic mutism due to bilateral mesial frontal strokes or apathetic depression from bilateral striatal lacunar strokes), or pseudovascular pseudoparkinsonism (e.g., higher-level gait disorders, including normal pressure hydrocephalus with transependimal exudate). These syndromic designations are preferable over vascular parkinsonism until pathology or validated biomarkers confirm the underlying nature and relevance of the leukoaraiosis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478160

DOI: 10.1002/mds.26263
PubMed: 25997420
PubMed Central: 4478160

Affiliations:

Canada, Pérou, États-Unis
Caroline du Nord, Ohio

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vascular parkinsonism: Deconstructing a syndrome</title>
<author><name sortKey="Vizcarra, Joaquin A" sort="Vizcarra, Joaquin A" uniqKey="Vizcarra J" first="Joaquin A." last="Vizcarra">Joaquin A. Vizcarra</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Facultad de Medicina “Alberto Hurtado”, Universidad Peruana Cayetano Heredia, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea> Facultad de Medicina “Alberto Hurtado”, Universidad Peruana Cayetano Heredia, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, University Health Network, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, University Health Network, University of Toronto, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D" last="Sethi">Kapil D. Sethi</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Georgia Regents University, Department of Neurology, August, Georgia; and Merz Pharmaceuticals, Raleigh, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Georgia Regents University, Department of Neurology, August, Georgia; and Merz Pharmaceuticals, Raleigh, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:aff id="A4"> Gardner Family Center for Parkinson’s Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Gardner Family Center for Parkinson’s Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25997420</idno>
<idno type="pmc">4478160</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478160</idno>
<idno type="RBID">PMC:4478160</idno>
<idno type="doi">10.1002/mds.26263</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000844</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000844</idno>
<idno type="wicri:Area/Pmc/Curation">000844</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000844</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000177</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000177</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000487</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000487</idno>
<idno type="wicri:Area/PubMed/Curation">000487</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000487</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000487</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000487</idno>
<idno type="wicri:Area/Ncbi/Merge">001B76</idno>
<idno type="wicri:Area/Ncbi/Curation">001B76</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001B76</idno>
<idno type="wicri:doubleKey">0885-3185:2015:Vizcarra J:vascular:parkinsonism:deconstructing</idno>
<idno type="wicri:Area/Main/Merge">000478</idno>
<idno type="wicri:Area/Main/Curation">000477</idno>
<idno type="wicri:Area/Main/Exploration">000477</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Vascular parkinsonism: Deconstructing a syndrome</title>
<author><name sortKey="Vizcarra, Joaquin A" sort="Vizcarra, Joaquin A" uniqKey="Vizcarra J" first="Joaquin A." last="Vizcarra">Joaquin A. Vizcarra</name>
<affiliation wicri:level="1"><nlm:aff id="A1"> Facultad de Medicina “Alberto Hurtado”, Universidad Peruana Cayetano Heredia, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea> Facultad de Medicina “Alberto Hurtado”, Universidad Peruana Cayetano Heredia, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation wicri:level="1"><nlm:aff id="A2"> Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, University Health Network, University of Toronto, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, University Health Network, University of Toronto, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D" last="Sethi">Kapil D. Sethi</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Georgia Regents University, Department of Neurology, August, Georgia; and Merz Pharmaceuticals, Raleigh, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Georgia Regents University, Department of Neurology, August, Georgia; and Merz Pharmaceuticals, Raleigh, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:aff id="A4"> Gardner Family Center for Parkinson’s Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Gardner Family Center for Parkinson’s Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrovascular Disorders (classification)</term>
<term>Cerebrovascular Disorders (pathology)</term>
<term>Cerebrovascular Disorders (physiopathology)</term>
<term>Humans</term>
<term>Parkinsonian Disorders (classification)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Parkinsonian Disorders (physiopathology)</term>
<term>Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Cerebrovascular Disorders</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebrovascular Disorders</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebrovascular Disorders</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Syndrome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Progressive ambulatory impairment and abnormal white matter signal on neuroimaging come together under the diagnostic umbrella of vascular parkinsonism. A critical appraisal of the literature, however, suggests that (1) no abnormal structural imaging pattern is specific to vascular parkinsonism; (2) there is poor correlation between brain magnetic resonance imaging hyperintensities <italic>and</italic>
 microangiopathic brain disease <italic>and</italic>
 parkinsonism from available clinicopathologic data; (3) <italic>pure</italic>
 parkinsonism from vascular injury (“definite” vascular parkinsonism) consistently results from ischemic or hemorrhagic strokes involving the substantia nigra and/or nigrostriatal pathway but sparing the striatum itself, the cortex, and the intervening white matter; and (4) many cases reported as vascular parkinsonism may represent <italic>pseudovascular</italic>
 parkinsonism (e.g., Parkinson disease or another neurodegenerative parkinsonism such as progressive supranuclear palsy with non-specific neuroimaging signal abnormalities), vascular <italic>pseudoparkinsonism</italic>
 (e.g., akinetic mutism due to bilateral mesial frontal strokes or apathetic depression from bilateral striatal lacunar strokes), or <italic>pseudovascular pseudoparkinsonism</italic>
 (e.g., higher-level gait disorders, including normal pressure hydrocephalus with transependimal exudate). These syndromic designations are preferable over <italic>vascular parkinsonism</italic>
 until pathology or validated biomarkers confirm the underlying nature and relevance of the leukoaraiosis.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>Pérou</li>
<li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Ohio</li>
</region>
</list>
<tree><country name="Pérou"><noRegion><name sortKey="Vizcarra, Joaquin A" sort="Vizcarra, Joaquin A" uniqKey="Vizcarra J" first="Joaquin A." last="Vizcarra">Joaquin A. Vizcarra</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D" last="Sethi">Kapil D. Sethi</name>
</region>
<name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J." last="Espay">Alberto J. Espay</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000477 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000477 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4478160
   |texte=   Vascular parkinsonism: Deconstructing a syndrome
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25997420" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Vascular parkinsonism: Deconstructing a syndrome

Vascular parkinsonism: Deconstructing a syndrome

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.